Top 20 Biotech Companies - 2019

Biotechnology has had a substantial impact on many integral aspects of human welfare. Humans have been using this stream of science in agriculture, food chain, and medicine for over a thousand years. The field involves the study of DNA (Deoxyribonucleic acid) to understand and manipulate the genetic makeup of cells to increase the beneficial characteristics of plants or organisms that might be useful to humans.

Powerful data analysis tools are being used that can decode an entire genome in a matter of hours, making it one of the most essential tools for the biotech industry. Artificial intelligence (AI) can be used to predict the structures of molecules to accelerate research efforts, increase the potential of clinical trials, to analyze relationships between various entities, generating interactive research graphs and creative dashboards with centralized information to stimulate drug discovery and faster development.

Agricultural biotech firms use data science tools to identify the best productive crops with less impact on the environment, especially among the genetically modified plants. In drug approvals, only a few drugs make it to market, while remaining nearly 50% of compounds are lost in phase II and phase III trials for lack of potency. There are several reasons why drugs fail to be marketed, such as picking the wrong targets, research failure, poor data quality, and making wrong decisions about compounds. Data analytics, when applied to experiments and clinical trials, can help quickly identify the source of error with greater ease. The technology also helps to build predictive models and provide information on optimum parameters that will achieve the desired outcome of an experiment. In addition, biotech companies can also use these insightful metrics to be able to identify bottlenecks and overcome challenges.

Technological breakthroughs in Biotechnology have altered the way we live our lives; from bacteria that can eat oil, to innovations such as growing human organs in labs for transplantations and biofuel that reduce carbon footprint and global warming effects. In today’s world, as a population continues to grow, biotechnology is being utilized to develop food such as vegetables and meat in laboratories to curb the food shortage problem. These food products are created with a class that matches them to the original item and is set to quickly change the way humans consume food. Further, innovations of biotech in making breakthrough medical products like speech restorer, smart pill, absorbable heart stent, portable dialysis machine and many more have transformed the way humans react to diseases.

 In this edition of CIO Review, we present you the “20 Most Promising BioTech Solution Providers 2019,” featuring the best solution providers offering tools and services in the biotech landscape. The companies compiled in this issue have exhibited extensive business process knowledge, along with in-depth, integrated, and innovative strategies. The listing provides a look into how the solutions and services work in the real world so that organizations can gain a comprehensive understanding of what technologies are available and how they shape up against the competition.

Top Biotech Solution Companies

Top Biotech Solution Companies

BrightInsight is a medical-grade Internet of Things (IoT) platform that integrates data from connected medical devices and therapeutics to deliver intelligence for pharmaceutical and medical technology companies. BrighInsight has built a powerful platform to solve these challenges and help MedTech and Pharma companies run and scale their digital health initiatives successfully. BrightInsight's platform acts as the functional springboard for companies to launch their solutions and integrate them with the relevant source of data. BrightInsight’s advanced medical-grade managed services solution analyzes connected medical device data and therapies, delivering real-time insights within a regulatory-compliant environment

Drug developers and clinicians are looking for a biomarker that can capture more of a patient’s immunological profile, their response to therapy, and potentially, the overall prognosis of the health outcome. Hence, Cofactor Genomics strongly advocates the use of multidimensional biomarkers using high-throughput technology like RNA sequencing. Cofactor’s premier product, called ImmunoPrism, provides access to both the superior immune profiling and Predictive Immune Modeling technologies. It delivers improved biological insights for immune-oncology using Cofactor's Health Expression models and generates RNA-based multidimensional biomarkers with some of the highest predictive accuracies that the industry has seen. ImmunoPrism is available as a clinical assay as well as a research kit for use in the thousands of labs profiling tumors

Illinois-based MopHius Analytics takes a unique approach to help clients overcome the hurdles to optimize bioprocess performance. The company focuses on process analytical technology (PAT) through quality by design (QPD) infrastructure along with its extensive knowledge of cell line development bioprocessing, to help clients streamline the development of biopharmaceuticals. MopHius Analytics offers a product line comprised of process sensors focused on long-term and single-use applications for bioreactor processes. These solutions are highly flexible and can be easily deployed in client firms ranging from small biotech companies to large drug manufacturers

Ranomics, a Toronto based Biotech Company, was formed to identify functionally important variants on target genes. Ranomics offer high throughput screening services and tools for wide range of applications including protein engineering and characterization, drug discovery and synthetic biological applications. Variant Enabled Rapid Genomics (or VERG) is Ranomic's flagship high-throughput functional genomics platform while Variant Find is the company's patent-pending library building technology. Combining state-of-the-art Variant Find library building technology with VERG functional genomics platform, Ranomics has proved to be a game-changer in the space of functional genomics

The development and execution of a clinical trial involves collaboration between sponsors—which can be individuals or pharmaceutical companies developing a drug—and CROs. However, the siloed operations and lack of an avenue to bridge the gap between the two entities is introducing inefficiencies into trial performance. In order to address this challenge and break down the walls between CROs and sponsors, Strategikon Pharma has developed Clinical Maestro. With this product, Strategikon Pharma delivers a novel, faster, and more accurate way to plan, model, and manage clinical trials

The Virginia-based staffing and professional services firm Validation Associates was instituted with a dedication to help industries to find the best talents that suite their basic requirements. Realizing the setback associated with the legacy staffing methods and the need for development and implementation of new capabilities in recruitment space the company provides staffing services to businesses, especially to the Pharmaceuticals, Biotech and Medical Devices enterprises. The firm focuses on contract staffing, contract to hire, direct hire search as well as small project consulting services and provides highly qualified, reliable talent at the right compensation level. Validation Associates’ staffing and recruiting services also allow organizations to reduce fixed expenses and cut down costs while attracting and retaining the best people in their businesses

10x Genomics

10x Genomics

At 10X Genomics, they are ambitious, talented software engineers who work to build revolutionary DNA sequencing technology. Their multi-disciplinary team in microfluidics, biochemistry, mechanical engineering, computational biology, and software has a proven track record of delivering successful commercial products built on deep technological innovation. While DNA sequencing technology has advanced rapidly, it is still at a level equivalent to what assembly language was to computing, with tremendous advances yet to be made. 10X is creating products that will do for sequencing, bringing a leap in higher-order clarity and software is a crucial part of that leap

Advanced Instruments

Advanced Instruments

Known as one of the world’s foremost authorities, Advanced Instruments is the maker of the application, Freezing Point Depression technology for measuring the osmolality of solutions. Since the company’s inception, laboratory professionals have looked to Advanced Instruments for exceptional customer support and leading-edge tools for the diagnostic laboratory. Innovative solutions for common laboratory problems remain a constant the mission of the company. Every product is backed by a team of specialists with the experience to quickly implement and optimize their systems for the specific laboratory needs. It is a market leader with an experienced workforce, low employee turnover, and financial stability

Applikon Biotechnology

Applikon Biotechnology

When it comes to an improved quality of life, Applikon Biotechnology proudly promotes it. As a world leader in the development and supply of advanced bioreactor systems, Applikon passionately contributes to the Life Sciences. Their goal is to continuously introduce new technologies to the market, covering the spectrum from laboratory scale via pilot plant to production scale. In addition to advanced cultivation systems, their core business also includes Process Control and Process Information Management systems. Significant investments in R&D and in-house development and production enable the company to be flexible and efficient for individual customer delivery solution

Auransa, Inc.

Auransa, Inc.

Auransa is fundamentally changing the way drugs are discovered for conditions like cancer and Alzheimer’s disease. They address the entire spectrum of drug development, from analyzing molecular data to identifying compounds for clinical development. Auransa’s sophisticated, proprietary platform and diagnostic technology generate insights from molecular data for a deep understanding of disease biology and patient subtypes. This information drives the discovery of compounds designed to most effectively address significant unmet medical needs. They predict more biologically and clinically relevant treatments in a faster and more cost-effectively manner. It also monitors the patients’ responses to treatment in trials and medical practice

Beckman Coulter

Beckman Coulter

At Beckman Coulter, they are dedicated to advancing and optimizing the laboratory. For more than 80 years, they have been a trusted partner for laboratory professionals, helping to develop scientific research and patient care. They have a vital role to focus on innovation, reliability, and efficiency that leads them toward becoming the partner of choice for clinical, research, and industrial customers around the globe. In the life sciences, researchers use Beckman Coulter’s precision instruments to study complex biological problems, including causes of disease and potential new treatments

Benchling

Benchling

Benchling makes life science research faster and more collaborative. Biotechnology has the potential to solve humanity’s most pressing challenges, such as disease, renewable energy, clean water, and hunger. The brightest minds are working on these problems, but they are equipped with archaic tools. Benchling aspires to fix this and increase the rate of scientific output with a web-based platform that allows researchers to design and run experiments, analyze data, and share results. Hundreds of thousands of scientists all around the world use Benchling to do research. Researchers and scientists use it to be empowered by their tools

BioTek Instruments

BioTek Instruments

BioTek Instruments, Inc. is a worldwide leader in the design, manufacture, and distribution of innovative life science instrumentation. The company’s comprehensive product line includes cell imaging systems, microplate readers, washers, dispensers, automated incubators, stackers, and pipetting systems. Every product enables life science research by providing high performance, cost-effective analysis, and quantification of biomolecules. It also includes biomolecular interactions and cellular structure, along with functions across diverse applications. BioTek espouses a “Think Possible”​approach that sets the tone for fresh ideas, unsurpassed customer service, and original innovations

Brooks Life Sciences

Brooks Life Sciences

Brooks Life Sciences partner with scientists and researchers to support the search for cures with the industry’s most complete portfolio of sample management solutions. Their products, services, and technology are empowering advancements and creating hope for the delivery of healthier and brighter tomorrows for people everywhere. The world’s top researchers trust Brooks to help them nurture chemical compounds and biological samples that bring forth new medicines and therapies. They count on their global team of experts to customize solutions that safely handle any stage in the sample lifespan of planning, collection, transport, processing, storage, analytics, retrieval, and disposal

Catalent

Catalent

As the world’s leading drug development, delivery, and supply partner, Catalent is a catalyst for every success. They have helped thousands of innovators by optimizing and manufacturing thousands of pharmaceutical, biologic, consumer health, and beauty products utilizing their superior and innovative drug delivery technologies to improve their value to patients and consumers. The company’s Patient First culture puts patients at the center of their work to ensure the safety, reliable supply, and optimal performance of their products. Catalent’s legacy of drug development goes much deeper, incorporating the inventions and innovations which have transformed the pharmaceutical industry

Data2Discovery

Data2Discovery

Data2Discovery is the global leader in applying knowledge graphs, AI & data science to drug discovery. With decades of experience and a platform that includes linked data, graph technologies, ML, and AI, it is meeting the most crucial business challenges for the drug discovery industry. They are pioneering a transformative new big data approach to understand and treat disease by connecting data in ways never tried before creating new keys to effective disease treatment. By linking diverse datasets from molecule to genome to patient, and applying machine learning patent-pending algorithms, they uncover hidden connections and new insights

Distek

Distek

Distek, Inc. is a leading manufacturer of laboratory testing instruments for the pharmaceutical and biotechnology industry for over 40 years, as well as an experienced provider of validation and qualification services. Distek engineers are highly innovative, technically modern, and leverage user-friendly instruments that provide many innovative features to customers worldwide. It includes water bath and bathless dissolution, media preparation and disposal, in-situ fiber optic UV, bathless tablet disintegration, content uniformity, and dissolution auto-sampling. The company’s bioprocessing portfolio includes the BIOne single-use bioreactor for cell culture applications and an innovative bioreactor control system for both mammalian and microbial models

Engine Biosciences

Engine Biosciences

Engine Biosciences is a technology company pioneering network biomedicine. Their proprietary and patented technologies oriented around deciphering the complexity of biology networks include both high-throughput wet-lab experimentation and AI algorithms for drug discovery and cellular reprogramming. Their unique platform has developed through several years of research by their scientific founding and leadership team. The team includes faculty members at MIT, Harvard, Mayo Clinic, and UCSD dramatically accelerates and reduces the costs of the R&D process for new medical therapies. They are actively applying the platform internally and with partners across a range of disease indications

HighRes Biosolutions

HighRes Biosolutions

HighRes Biosolutions love automation. They design and build innovative robotic systems and laboratory devices used by pharmaceutical and biotech companies and academic research laboratories. They help scientists accelerate such areas as drug discovery, high-throughput genotyping, siRNA screening, next-generation sequencing sample prep, biorepository science, molecular diagnostics, and more. The company offers highly flexible, expandable, and modular integrated systems and bench-top devices that are easily configured and reconfigured for fast-paced, dynamic laboratories. They aim to have automation designed to let scientists focus on science, while robots do the routine tasks and architecture rooted in flexibility that can be adapted easily

Thrive Bioscience

Thrive Bioscience

Thrive Bioscience is the first company to meet the need for automated, programmable cell culture & maintenance systems combined with extensive image capture & analytics, all within a closed incubation environment. Thrive’s innovative systems provide reproducible protocols, scalable cell propagation, analytics, and complete process history documentation with supporting images. Their system also provides an interactive partnership between cell technicians and grows, maintain, and manipulate cells. Through automation, careful monitoring and analysis, Thrive systems remove causes of variation inherent in manual cell culture. They are taking the art out of cell culture and delivering high-quality science